Thermocoagulation is based on the application of a high-frequency signal between two adjacent macro contacts of a SEEG electrode, generating a localized thermal increase that leads to coagulation of the surrounding tissue. In epilepsy treatment, this thermocoagulation technique has proven effective in disrupting the neural circuits responsible for epileptogenic activity.

While not suitable for all patient profiles, its demonstrated efficacy and favorable safety profile make it a valuable therapeutic option for cases of focal epilepsy resistant to medication. Beyond its therapeutic role, thermocoagulation can also be used for diagnostic purposes or as a palliative solution, particularly when conventional surgical options are limited. Ongoing research and technological advancements continue to expand its indications, opening new possibilities for patients with otherwise limited treatment options.